Gene therapy on germline cells generates a lot of controversies because any changes become heritable (since progeny receive the manipulated DNA). After a long, sobering phase with little of either hype or hope, the gene therapy field has enjoyed a resurgence in recent years, where with a much more mature understanding of the constraints and safety concerns, people have started to be able to design safe and effective gene therapies and there are now two FDA-approved therapies. In somatic cell therapy, the somatic cells are targeted for gene replacement, whereas in the reproductive cell therapy, the defective gene lies in the reproductive cells that are replaced by the correct gene. Gene therapy is the process of replacing defective genes with healthy ones, adding new genes to help the body fight or treat disease, or deactivating problem genes. Gene therapy trials in children present an ethical dilemma, according to some gene therapy experts. The goal with this approach is to create a future world where doctors could treat specific disorders by inserting genes into a patient's cells instead of using surgery, drugs, or other interventions to improve health. Most genetic diseases cannot be treated, but gene therapy research gives some hope to patients and their families as a possible cure. It replaces a gene that doesn’t work with one that does. Gene therapy is using "genes as medicine". This therapy can be broadly classified into two types: somatic cell therapy and reproductive cell or germline therapy. (ii) demonstrated that gene therapy is relatively safe, and (iii) highlighted several important issues that. It is an experimental approach to treating genetic disease where the faulty gene is fixed, replaced or supplemented with a healthy gene so that it can function normally. Gene therapy is an experimental way to treat some diseases without traditional drugs or surgery. must be considered to advance the ﬁeld. Gene Therapy for the Treatment of Genetic Disorders. Gene therapy has been associated with several problems over the last few decades. So just because some kids appear to have a genetic problem doesn't mean they'll be substantially affected by it, but they'll have to live with the knowledge of that problem. On the surface, the concept is simple. This makes it possible, for instance, to not only correct a genetic defect that causes bubble boy syndrome in the patient but to also eliminate the defect permanently in subsequent generations of that family. Kids with an altered gene may have mild or severe effects and the severity often can't be determined in infants. Gene therapy is an experimental technique in medical science that uses genes to either prevent or treat disease.