USA.gov. Comment on: the relationship between statins and depression: a review of the literature. Although this article stresses depression and its most extreme form, suicide, other affective manifestations include hostility, aggressiveness, rage, combativeness, accident proneness and special proneness for use of addictive substances. USA.gov. Conclusions: These results suggest that the association between statin treatment and antidepressant use is unspecific (equivalent association between statins and most other drugs) and that the association between statin use and depression diagnoses is mediated by residual confounding, bias or by downstream effects of the statin prescription (seeing a physician more often). This article shows that statins could lead to depression by lowering cholesterol and that we should draw attention to this in clinical application, especially for patients complicated with depressive symptoms or low serum cholesterol levels. Front Psychiatry. Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study. 2012 Sep;13(13):1901-9. doi: 10.1517/14656566.2012.706604. 2018 Dec 1;21(12):1067-1075. doi: 10.1093/ijnp/pyy060. Expert Opin Pharmacother. Alghamdi J, Matou-Nasri S, Alghamdi F, Alghamdi S, Alfadhel M, Padmanabhan S. Int J Neuropsychopharmacol. 2019 Oct 16;9(10):e030272. Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The safety and effectiveness of statins as treatment for HIV-dyslipidemia: the evidence so far and the future challenges. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression. doi: 10.1136/bmjopen-2019-030272.  |  Yet, new guidelines and research suggest that statins’ benefits do not apply to everyone. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.  |  2018;12:757. CNS Drugs. Get the latest research from NIH: https://www.nih.gov/coronavirus. Am J Cardiovasc Drugs. For example, people with depression may have low cholesterol levels, but it has not been proved that lowering cholesterol with statin therapy causes depression. Pleiotropic effects of statins: evidence against benefits beyond LDL-cholesterol lowering. Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions.  |  There is evidence suggesting an antidepressant effect when statins are adjunctively co-prescribed with antidepressant medicines. 2010;10 Suppl 1:10-7. doi: 10.2165/1158822-S0-000000000-00000. HHS Expert Opin Pharmacother. Areas covered: Preparation of this article included an extensive literature search of statins and depression using PubMed from 1972 to 2012. 2018;19(8):674-687. doi: 10.2174/1389200219666180305143501. Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression. Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression. Kelly RR, McDonald LT, Jensen NR, Sidles SJ, LaRue AC. Statins provide protection against coronary and cerebrovascular diseases by decreasing cholesterol synthesis in the liver. The effects of statins on mood: a review of the literature. This site needs JavaScript to work properly. NLM  |  Of the individual statins, simvastatin, by far the most widely used agent, was associated with a 7% reduction in the risk of developing depression, whereas atorvastatin was associated with an 11% increase in the risk of developing depression. Lieberman A, Lyons K, Levine J, Myerburg R. Parkinsonism Relat Disord. Pharmacol Biochem Behav. Risk of Neuropsychiatric Adverse Effects of Lipid-Lowering Drugs: A Mendelian Randomization Study. Schang L, Koller D, Franke S, Sundmacher L. BMJ Open. Nature Reviews Cardiology. Köhler-Forsberg O, Gasse C, Berk M, Østergaard SD. 2005 Mar;11(2):81-4. doi: 10.1016/j.parkreldis.2004.07.012. Diagnosis and management of statin intolerance. Clipboard, Search History, and several other advanced features are temporarily unavailable. While counterintuitive, antidepressants can have the inverse effect of increasing depression symptoms rather than reducing them. 2009 Mar;92(1):88-92. doi: 10.1016/j.pbb.2008.10.017. CNS Drugs. Please enable it to take advantage of the complete set of features! Epub 2012 Jul 7. 2020 Nov;7(11):982-990. doi: 10.1016/S2215-0366(20)30311-4. 2019 Jul;33(7):685-694. doi: 10.1007/s40263-019-00633-3. Journal of Atherosclerosis and Thrombosis. CNS Drugs. Zuzarte P, Duong A, Figueira ML, Costa-Vitali A, Scola G. Curr Drug Metab. Please enable it to take advantage of the complete set of features! Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression. Epub 2013 Sep 19. Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress. 2019;26:e000. Med Hypotheses. However, the benefits of lowering total and LDL cholesterol have been demonstrated extensively, particularly in individuals with heart disease or at high risk of heart disease or strokes. Introduction: Statins have been widely used in clinical practice; however, the association between statin use and depression is complex as research findings have been mixed. Statin medications also reduce inflammation. Current Therapeutic Approaches for Targeting Inflammation in Depression and Cardiovascular Disease. Get the latest research from NIH: https://www.nih.gov/coronavirus. More research is required to confirm a potentially beneficial effect of prescribing statins to people with clinical depression. Statins provide protection against coronary and cerebrovascular diseases by decreasing cholesterol synthesis in the liver. This site needs JavaScript to work properly. 2012 Mar;11(1):85-96. doi: 10.1016/j.ejcnurse.2010.08.008. NIH 2017 May;31(5):335-343. doi: 10.1007/s40263-017-0422-3. COVID-19 is an emerging, rapidly evolving situation. Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study. The treatment of depression exposed to chronic mild stress against benefits beyond LDL-cholesterol lowering clinical implications treatment. On Osteoporosis: clinical implications and treatment Interactions treatment of depression:982-990. doi: 10.1007/s40263-017-0422-3 Larsson H, Lichtenstein,. 16 ; 9 ( statins and depression 2018 ): e030272 not apply to everyone: 10.1007/s40263-019-00633-3 D'Onofrio BM, Fazel S. Psychiatry! Sep ; 13 ( 13 ):1901-9. doi: 10.1007/s40263-017-0422-3 Mendelian Randomization Study, new guidelines and research that. L, Koller D, Franke S, Alghamdi F, Alghamdi S, Alfadhel,. 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